Assay Detail
Binding
CHEMBL5317032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation incubated for 4 hr by HTRF analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.37 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748154 | — | — | 1 | 6.52 |
| CHEMBL5409039 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748154 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5409039 | — | IC50 | = | 600.0 | nM | 6.22 |