Assay Detail
Binding
CHEMBL5317223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
YEATS domain-containing protein 4 (CHEMBL4296266) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.31 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5439842 | — | — | 1 | 7.52 |
| CHEMBL5434894 | — | — | 1 | 7.35 |
| CHEMBL5397585 | — | — | 1 | 7.28 |
| CHEMBL5428051 | — | — | 1 | 7.28 |
| CHEMBL5411016 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5439842 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL5434894 | — | Kd | = | 45.0 | nM | 7.35 |
| CHEMBL5397585 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5428051 | — | Kd | = | 52.7 | nM | 7.28 |
| CHEMBL5411016 | — | Kd | = | 80.0 | nM | 7.10 |