Assay Detail
Binding
CHEMBL5317286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT (unknown origin) using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins in presence of ATP by fluorescence based microplate reader analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.92 |
| CHEMBL1586371 | — | — | 1 | 7.21 |
| CHEMBL5406636 | — | — | 1 | 7.08 |
| CHEMBL5403078 | — | — | 1 | 7.03 |
| CHEMBL5394965 | — | — | 1 | 7.00 |
| CHEMBL5414864 | — | — | 1 | 6.96 |
| CHEMBL5437058 | — | — | 1 | 6.92 |
| CHEMBL5408654 | — | — | 1 | 6.92 |
| CHEMBL5425579 | — | — | 1 | 6.89 |
| CHEMBL5418877 | — | — | 1 | 6.89 |
| CHEMBL5414758 | — | — | 1 | 6.82 |
| CHEMBL5405525 | — | — | 1 | 6.82 |
| CHEMBL5423357 | — | — | 1 | 6.80 |
| CHEMBL5405720 | — | — | 1 | 6.72 |
| CHEMBL5431029 | — | — | 1 | 6.72 |
| CHEMBL5402956 | — | — | 1 | 6.72 |
| CHEMBL5401852 | — | — | 1 | 6.64 |
| CHEMBL5396943 | — | — | 1 | 6.51 |
| CHEMBL5412973 | — | — | 1 | 6.01 |
| CHEMBL4565531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1586371 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5406636 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5403078 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5394965 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5414864 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5437058 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5408654 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5425579 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5418877 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5414758 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5405525 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5423357 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5405720 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5431029 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5402956 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5401852 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5396943 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5412973 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4565531 | — | IC50 | > | 2000.0 | nM | - |