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Assay Detail

CHEMBL5317670

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability measured after 5 days by Cell-Titer glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Physachenolide C is a Potent, Selective BET Inhibitor.
Zerio CJ, Sivinski J, Wijeratne EMK, Xu YM, Ngo DT, Ambrose AJ, Villa-Celis L, Ghadirian N, Clarkson MW, Zhang DD, Horton NC, Gunatilaka AAL, Fromme R, Chapman E.
J Med Chem (2023) 66 : 913 -933
PubMed 36577036 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4094346 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4094346 EC50 = 50.0 nM 7.30