Assay Detail
Binding
CHEMBL5317801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase PDB 7RFL using 5'-CGA TTC AAA AAG TCC CAA G-3' and 3'-GCT AAG TTT TTC AGG GTT C-5' as substrate and SAM as cosubstrate preincubated for 5 mins followed by substrate and cosubstrate addition and measured after 3 mins by MTase-Glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridioides difficile |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Systematic Design of Adenosine Analogs as Inhibitors of a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.33 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087498 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087498 | — | IC50 | = | 4700.0 | nM | 5.33 |