Assay Detail
Binding
CHEMBL5317809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase mediated methylation using 5'-CGA TTC AAA AAG TCC CAA G-3' and 3'-GCT AAG TTT TTC AGG GTT C-5' as substrate and SAM as cosubstrate preincubated for 5 mins followed by substrate and cosubstrate addition and measured after 3 mins by MTase glo assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridioides difficile |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Systematic Design of Adenosine Analogs as Inhibitors of a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.54 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411006 | — | — | 1 | 6.41 |
| CHEMBL5414547 | — | — | 1 | 6.29 |
| CHEMBL2113484 | — | — | 1 | 6.16 |
| CHEMBL5406914 | — | — | 1 | 6.15 |
| CHEMBL5410577 | — | — | 1 | 5.89 |
| CHEMBL5408147 | — | — | 1 | 5.85 |
| CHEMBL2113406 | — | — | 1 | 5.80 |
| CHEMBL5404814 | — | — | 1 | 5.70 |
| CHEMBL1257013 | — | — | 1 | 5.60 |
| CHEMBL5408731 | — | — | 1 | 5.42 |
| CHEMBL224024 | — | — | 1 | 5.32 |
| CHEMBL119709 | IB-MECA | — | 1 | 5.10 |
| CHEMBL259188 | — | — | 1 | 5.00 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 4.82 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.75 |
| CHEMBL2235599 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411006 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5414547 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2113484 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5406914 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5410577 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5408147 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2113406 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5404814 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1257013 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5408731 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL224024 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL119709 | IB-MECA | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL259188 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL388757 | N6-BENZYLADENOSINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL277041 | METHYLTHIOADENOSINE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2235599 | — | IC50 | = | 43000.0 | nM | 4.37 |