Assay Detail
Binding
CHEMBL5317810
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Binding affinity to Clostridioides difficile-specific DNA adenine methyltransferase by MicroCal PEAQ-ITC instrument analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridioides difficile |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Systematic Design of Adenosine Analogs as Inhibitors of a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 5.63 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406914 | — | — | 1 | 6.85 |
| CHEMBL5411006 | — | — | 1 | 6.85 |
| CHEMBL5414547 | — | — | 1 | 6.64 |
| CHEMBL2113484 | — | — | 1 | 6.30 |
| CHEMBL5404814 | — | — | 1 | 5.96 |
| CHEMBL5410577 | — | — | 1 | 5.89 |
| CHEMBL5408147 | — | — | 1 | 5.82 |
| CHEMBL2113406 | — | — | 1 | 5.80 |
| CHEMBL1257013 | — | — | 1 | 5.54 |
| CHEMBL119709 | IB-MECA | — | 1 | 5.41 |
| CHEMBL224024 | — | — | 1 | 5.28 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.96 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 4.89 |
| CHEMBL259188 | — | — | 1 | 4.85 |
| CHEMBL1256714 | — | — | 1 | 4.75 |
| CHEMBL2235599 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406914 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL5411006 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL5414547 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL2113484 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL5404814 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL5410577 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL5408147 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL2113406 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL1257013 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL119709 | IB-MECA | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL224024 | — | Kd | = | 5300.0 | nM | 5.28 |
| CHEMBL277041 | METHYLTHIOADENOSINE | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL388757 | N6-BENZYLADENOSINE | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL259188 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL1256714 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL2235599 | — | Kd | = | 49000.0 | nM | 4.31 |