Assay Detail
Binding
CHEMBL5317852
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Inhibition of ABCG2 in MDCK-II-BCRP cells incubated for 120 mins by pheophorbide A based fluorescence flow cytometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK-II-BCRP |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.05 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488910 | — | — | 1 | 6.79 |
| CHEMBL5405329 | — | — | 1 | 4.36 |
| CHEMBL5421503 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488910 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL5405329 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL5421503 | — | IC50 | = | 99500.0 | nM | 4.00 |