Assay Detail

CHEMBL5317890

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Toxicity

Inhibition of voltage dependent L/T-type calcium channel in human SH-SY5Y cells

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Cell Type	SH-SY5Y
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species.

Sidhom PA, El-Bastawissy E, Ibrahim MAA, Shawky AM, Salama A, El-Moselhy T.
J Med Chem (2023) 66 : 991 -1010
PubMed 36584305 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.72	4.78

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5414025	—	—	1	4.78
CHEMBL193	NIFEDIPINE	4.0	1	4.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5414025	—	IC50	=	16530.0	nM	4.78
CHEMBL193	NIFEDIPINE	IC50	=	21920.0	nM	4.66