Assay Detail
Functional
CHEMBL5318010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-468 cells expressing PHGDH assessed as reduction in cell viability measured for 72 hrs by CCK-8 assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.85 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418330 | — | — | 1 | 5.52 |
| CHEMBL5394206 | — | — | 1 | 5.32 |
| CHEMBL5436320 | — | — | 1 | 5.28 |
| CHEMBL5415992 | — | — | 1 | 5.26 |
| CHEMBL5422286 | — | — | 1 | 5.09 |
| CHEMBL5401773 | — | — | 1 | 5.08 |
| CHEMBL5413529 | — | — | 1 | 5.01 |
| CHEMBL5411304 | — | — | 1 | 5.00 |
| CHEMBL5409883 | — | — | 1 | 4.94 |
| CHEMBL5435562 | — | — | 1 | 4.93 |
| CHEMBL5412915 | — | — | 1 | 4.82 |
| CHEMBL4070806 | — | — | 1 | 4.68 |
| CHEMBL4545772 | — | — | 1 | 4.55 |
| CHEMBL5440487 | — | — | 1 | 4.52 |
| CHEMBL5404538 | — | — | 1 | 4.18 |
| CHEMBL5419077 | — | — | 1 | 4.16 |
| CHEMBL5413530 | — | — | 1 | 4.14 |
| CHEMBL5404397 | — | — | 1 | - |
| CHEMBL5418314 | — | — | 1 | - |
| CHEMBL4533417 | — | — | 1 | - |
| CHEMBL5405367 | — | — | 1 | - |
| CHEMBL5424581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418330 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5394206 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5436320 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5415992 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5422286 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5401773 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5413529 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5411304 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5409883 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5435562 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5412915 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4070806 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4545772 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL5440487 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL5404538 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL5419077 | — | IC50 | = | 69300.0 | nM | 4.16 |
| CHEMBL5413530 | — | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL5404397 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418314 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4533417 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5405367 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424581 | — | IC50 | > | 100000.0 | nM | - |