Assay Detail
Functional
CHEMBL5318200
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Cytoprotective activity against human HeLa Flp-In T-REx cells assessed as rescue of PARP10-induced cell death at 1 uM measured after 10 to 12 days by methylene blue staining based colony formation assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa Flp-In T-REx |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
[1,2,4]Triazolo[3,4-<i>b</i>]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.56 | 6.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404785 | — | — | 1 | 6.82 |
| CHEMBL5431108 | — | — | 1 | 6.30 |
| CHEMBL5406267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404785 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5431108 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5406267 | — | Activity | - | — | - |