Assay Detail
Binding
CHEMBL5318205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal MBP tagged/C-terminal PARP14 (unknown origin) expressed in Escherichia coli in presence of NAD+ by proximity enhanced assay
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP14 (CHEMBL2176777) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
[1,2,4]Triazolo[3,4-<i>b</i>]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.12 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404785 | — | — | 2 | 6.52 |
| CHEMBL5431108 | — | — | 2 | 6.19 |
| CHEMBL5406267 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404785 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5404785 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL5431108 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5431108 | — | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL5406267 | — | IC50 | = | 6700.0 | nM | 5.17 |