Assay Detail

CHEMBL5318331

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Functional

Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay

ChEMBL ↗

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Target

K562 (CHEMBL385) ↗

Open DB target context

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K562 (CHEMBL385) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target K562

CHEMBL385

Anchored from Assay target.

Protein identity K562

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	K562
Confidence	1 — Organism
Curated By	Autocuration

Target

K562 (CHEMBL385) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.

Huang Y, Liu N, Pan Z, Li Z, Sheng C.
J Med Chem (2023) 66 : 1239 -1253
PubMed 36622852 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.68	9.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL98	VORINOSTAT	4.0	1	9.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL98	VORINOSTAT	IC50	=	0.21	nM	9.68