Assay Detail
Functional
CHEMBL5318856
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Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 6 days by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KMS-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.73 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422549 | — | — | 1 | 6.57 |
| CHEMBL5418912 | — | — | 1 | 6.46 |
| CHEMBL337173 | — | — | 1 | 5.84 |
| CHEMBL5433538 | — | — | 1 | 5.78 |
| CHEMBL5415704 | — | — | 1 | 5.66 |
| CHEMBL5402620 | — | — | 1 | 5.62 |
| CHEMBL131199 | — | — | 1 | 5.60 |
| CHEMBL5406268 | — | — | 1 | 5.41 |
| CHEMBL5412847 | — | — | 1 | 5.22 |
| CHEMBL5418169 | — | — | 1 | 5.09 |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422549 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5418912 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL337173 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5433538 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5415704 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL5402620 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL131199 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL5406268 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL5412847 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL5418169 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | > | 20000.0 | nM | - |