Assay Detail
Toxicity
CHEMBL5319037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel stably expressed in HEK293 cells by whole-cell manual patch-clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.39 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.39 |
| CHEMBL5393904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5393904 | — | IC50 | > | 30000.0 | nM | - |