Assay Detail
Binding
CHEMBL5319065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.53 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1950289 | TANZISERTIB | 2.0 | 1 | 8.15 |
| CHEMBL252761 | — | — | 1 | 7.40 |
| CHEMBL3545213 | BENTAMAPIMOD | 2.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1950289 | TANZISERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL252761 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3545213 | BENTAMAPIMOD | IC50 | = | 90.0 | nM | 7.05 |