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Assay Detail

CHEMBL5319102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GSK3B (unknown origin) by caliper microfluidic mobility shift technology
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.
Thoma G, Duthaler RO, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, Orjuela Leon A, Viebrock S, Aichholz R, Beltz K, Grove K, Hoque S, Rudewicz PJ, Zerwes HG.
J Med Chem (2023) 66 : 2161 -2168
PubMed 36657024 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.42 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5270549 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5270549 IC50 = 380.0 nM 6.42