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Assay Detail

CHEMBL5319118

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant HDAC2 expressed in baculovirus using AMC-K(Ac)GL as substrate by microplate reader analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 2 (CHEMBL1937)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.
Macegoniuk K, Tabor W, Mazzei L, Cianci M, Giurg M, Olech K, Burda-Grabowska M, Kaleta R, Grabowiecka A, Mucha A, Ciurli S, Berlicki Ł.
J Med Chem (2023) 66 : 2054 -2063
PubMed 36661843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.10 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51085 EBSELEN 3.0 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51085 EBSELEN Ki = 80.0 nM 7.10