Assay Detail
Functional
CHEMBL5319322
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Antiproliferative activity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.54 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2097911 | — | — | 1 | 6.52 |
| CHEMBL5404387 | — | — | 1 | 6.22 |
| CHEMBL5419212 | — | — | 1 | 6.22 |
| CHEMBL5431371 | — | — | 1 | 6.05 |
| CHEMBL5435516 | — | — | 1 | 5.96 |
| CHEMBL5427129 | — | — | 1 | 5.92 |
| CHEMBL5395401 | — | — | 1 | 5.92 |
| CHEMBL5417481 | — | — | 1 | 5.85 |
| CHEMBL5434126 | — | — | 1 | 5.82 |
| CHEMBL5403056 | — | — | 1 | 5.80 |
| CHEMBL5402597 | — | — | 1 | 5.77 |
| CHEMBL5408011 | — | — | 1 | 5.75 |
| CHEMBL5397812 | — | — | 1 | 5.72 |
| CHEMBL5403411 | — | — | 1 | 5.70 |
| CHEMBL5425008 | — | — | 1 | 5.64 |
| CHEMBL5410957 | — | — | 1 | 5.64 |
| CHEMBL5397921 | — | — | 1 | 5.62 |
| CHEMBL5414068 | — | — | 1 | 5.58 |
| CHEMBL5437741 | — | — | 1 | 5.54 |
| CHEMBL5437241 | — | — | 1 | 5.52 |
| CHEMBL5406204 | — | — | 1 | 5.52 |
| CHEMBL5404573 | — | — | 1 | 5.50 |
| CHEMBL5408432 | — | — | 1 | 5.47 |
| CHEMBL5439290 | — | — | 1 | 5.43 |
| CHEMBL5413838 | — | — | 1 | 5.42 |
| CHEMBL5439899 | — | — | 1 | 5.42 |
| CHEMBL5427872 | — | — | 1 | 5.41 |
| CHEMBL5421590 | — | — | 1 | 5.31 |
| CHEMBL5412229 | — | — | 1 | 5.31 |
| CHEMBL5409819 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2097911 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5404387 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5419212 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5431371 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5435516 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5427129 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5395401 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5417481 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5434126 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5403056 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5402597 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5408011 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5397812 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5403411 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5410957 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5425008 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5397921 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5414068 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5437741 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5437241 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5406204 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5404573 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5408432 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5439290 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5439899 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5413838 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5427872 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5421590 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5412229 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5409819 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5423305 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5404085 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5416938 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5439009 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5396978 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5419799 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5406365 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5400982 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5395681 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5394968 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5432907 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5426774 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5402112 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5418697 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5431843 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 30000.0 | nM | - |
| CHEMBL5427311 | — | IC50 | > | 30000.0 | nM | - |