Assay Detail
Functional
CHEMBL5319348
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Antiproliferative activity against human BXPC-3 cells measured after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.38 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2097911 | — | — | 1 | 5.75 |
| CHEMBL5395401 | — | — | 1 | 5.24 |
| CHEMBL5431371 | — | — | 1 | 5.14 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2097911 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5395401 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5431371 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 30000.0 | nM | - |