Assay Detail
Toxicity
CHEMBL5319355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against HPDE cells measured after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HPDE |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.00 |
| CHEMBL5395401 | — | — | 1 | 6.52 |
| CHEMBL2097911 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5395401 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2097911 | — | IC50 | = | 600.0 | nM | 6.22 |