Assay Detail
Binding
CHEMBL5319645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bone morphogenetic protein receptor type-2 (CHEMBL5467) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.76 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434353 | — | — | 1 | 5.92 |
| CHEMBL5398151 | — | — | 1 | 5.80 |
| CHEMBL5404269 | — | — | 1 | 5.75 |
| CHEMBL5422418 | — | — | 1 | 5.55 |
| CHEMBL513147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434353 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5398151 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5404269 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5422418 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL513147 | — | IC50 | > | 1000000.0 | nM | - |