Assay Detail
Binding
CHEMBL5319745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells transfected with NF-kappaB luciferase reporter gene pretreated with compounds for 30 mins followed by LPS stimulation for 8 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tanzawaic Acid Derivatives from the Marine-Derived <i>Penicillium steckii</i> as Inhibitors of RANKL-Induced Osteoclastogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403183 | — | — | 1 | 5.30 |
| CHEMBL5428452 | — | — | 1 | 4.98 |
| CHEMBL5414463 | — | — | 1 | 4.82 |
| CHEMBL3353036 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403183 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5428452 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5414463 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3353036 | — | IC50 | = | 18600.0 | nM | 4.73 |