Assay Detail
Functional
CHEMBL5319996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human M21 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 6.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.40 |
| CHEMBL1802510 | — | — | 1 | 7.40 |
| CHEMBL5426611 | — | — | 1 | 6.30 |
| CHEMBL5416543 | — | — | 1 | 6.14 |
| CHEMBL4078072 | — | — | 1 | 5.62 |
| CHEMBL5407151 | — | — | 1 | - |
| CHEMBL5437198 | — | — | 1 | - |
| CHEMBL5422835 | — | — | 1 | - |
| CHEMBL5436479 | — | — | 1 | - |
| CHEMBL5415404 | — | — | 1 | - |
| CHEMBL5440111 | — | — | 1 | - |
| CHEMBL5425273 | — | — | 1 | - |
| CHEMBL5404691 | — | — | 1 | - |
| CHEMBL5417670 | — | — | 1 | - |
| CHEMBL5396818 | — | — | 1 | - |
| CHEMBL5430922 | — | — | 1 | - |
| CHEMBL5426868 | — | — | 1 | - |
| CHEMBL5419613 | — | — | 1 | - |
| CHEMBL5432312 | — | — | 1 | - |
| CHEMBL5430622 | — | — | 1 | - |
| CHEMBL5403064 | — | — | 1 | - |
| CHEMBL5417554 | — | — | 1 | - |
| CHEMBL5433537 | — | — | 1 | - |
| CHEMBL5422766 | — | — | 1 | - |
| CHEMBL5402551 | — | — | 1 | - |
| CHEMBL5407197 | — | — | 1 | - |
| CHEMBL5427126 | — | — | 1 | - |
| CHEMBL5396272 | — | — | 1 | - |
| CHEMBL5408517 | — | — | 1 | - |
| CHEMBL5422728 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1802510 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5426611 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5416543 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4078072 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5430922 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5396650 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5426868 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5437198 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5429813 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5426962 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5424154 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5432109 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5440201 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5398824 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5404371 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5419456 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5412227 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5403065 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5416804 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5409141 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5409335 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5430004 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5414230 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5437502 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5422224 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5430622 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5422728 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5408517 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5396272 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5427126 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5407197 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5402551 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5422766 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5433537 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5417554 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5403064 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5396818 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL5432312 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5419613 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5407151 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5422835 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL5436479 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5415404 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5440111 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5425273 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5404691 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL5417670 | — | IC50 | > | 12500.0 | nM | - |