Assay Detail
Toxicity
CHEMBL5320104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.83 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416581 | — | — | 1 | 6.44 |
| CHEMBL5437236 | — | — | 1 | 4.72 |
| CHEMBL5411999 | — | — | 1 | 4.60 |
| CHEMBL5432266 | — | — | 1 | 4.57 |
| CHEMBL5411365 | — | — | 1 | 4.55 |
| CHEMBL5403087 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416581 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5437236 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5411999 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5432266 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5411365 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5403087 | — | IC50 | = | 78000.0 | nM | 4.11 |