Assay Detail
Binding
CHEMBL5320296
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Inhibition of trophozoite stage Plasmodium falciparum 3D7 ATP4 ATPase assessed as dysregulation in cytosolic sodium ions concentration by SBFI dye based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.57 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416583 | — | — | 1 | 6.64 |
| CHEMBL5396418 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416583 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5396418 | — | EC50 | = | 320.0 | nM | 6.50 |