Assay Detail
Functional
CHEMBL5320312
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Antimalarial activity against asexual stage multidrug-resistant Plasmodium falciparum PNG 1776 assessed as reduction in parasitemia incubated for 72 hrs by LDH assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.70 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL579420 | — | — | 1 | 8.77 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.31 |
| CHEMBL5395617 | — | — | 1 | 8.00 |
| CHEMBL5436150 | — | — | 1 | 7.85 |
| CHEMBL5427940 | — | — | 1 | 7.77 |
| CHEMBL5396856 | — | — | 1 | 7.11 |
| CHEMBL5418901 | — | — | 1 | 6.95 |
| CHEMBL5416583 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL579420 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1450 | ATOVAQUONE | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5395617 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5436150 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5427940 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5396856 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5418901 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5416583 | — | EC50 | = | 148.0 | nM | 6.83 |