Assay Detail
Functional
CHEMBL5320316
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Antimalarial activity against late-stage Plasmodium falciparum NF54 V gametocyte assessed as reduction in female gamete formation preincubated with compound for 48 hrs followed by xanthurenic acid addition and measured after 24 hrs by automated microscopic analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.04 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427940 | — | — | 1 | 9.72 |
| CHEMBL5416583 | — | — | 1 | 9.06 |
| CHEMBL5396418 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427940 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL5416583 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL5396418 | — | EC50 | = | 4.69 | nM | 8.33 |