Assay Detail
Binding
CHEMBL5320433
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Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Insect cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.90 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393608 | — | — | 1 | 8.89 |
| CHEMBL2216824 | — | — | 1 | 8.33 |
| CHEMBL5432340 | — | — | 1 | 8.00 |
| CHEMBL5415466 | — | — | 1 | 7.75 |
| CHEMBL5397194 | — | — | 1 | 7.28 |
| CHEMBL5436341 | — | — | 1 | 7.21 |
| CHEMBL5396061 | — | — | 1 | 7.17 |
| CHEMBL5436350 | — | — | 1 | 7.13 |
| CHEMBL5410683 | — | — | 1 | 7.05 |
| CHEMBL5398275 | — | — | 1 | 6.80 |
| CHEMBL5413843 | — | — | 1 | 6.78 |
| CHEMBL5395598 | — | — | 1 | 6.62 |
| CHEMBL5433713 | — | — | 1 | 6.59 |
| CHEMBL5408895 | — | — | 1 | 6.41 |
| CHEMBL5406036 | — | — | 1 | 6.33 |
| CHEMBL5437715 | — | — | 1 | 6.32 |
| CHEMBL5410247 | — | — | 1 | 6.14 |
| CHEMBL5415188 | — | — | 1 | 5.94 |
| CHEMBL5398852 | — | — | 1 | 5.66 |
| CHEMBL5406812 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393608 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2216824 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5432340 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5415466 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5397194 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5436341 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5396061 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5436350 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5410683 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5398275 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5413843 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5395598 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL5433713 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL5408895 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL5406036 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5437715 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL5410247 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL5415188 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5398852 | — | IC50 | = | 2173.0 | nM | 5.66 |
| CHEMBL5406812 | — | IC50 | = | 3047.0 | nM | 5.52 |