Assay Detail
Binding
CHEMBL5320532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HCoV-229E MPro assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human coronavirus 229E |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.77 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.35 |
| CHEMBL213054 | — | — | 1 | 7.17 |
| CHEMBL1230135 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL213054 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL1230135 | — | Ki | = | 1670.0 | nM | 5.78 |