Assay Detail
Functional
CHEMBL5320538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral growth
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.92 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076204 | — | — | 1 | 6.54 |
| CHEMBL5191060 | — | — | 1 | 6.52 |
| CHEMBL4796938 | — | — | 1 | 6.28 |
| CHEMBL5270743 | — | — | 1 | 6.27 |
| CHEMBL5195325 | — | — | 1 | 6.07 |
| CHEMBL2435614 | — | — | 1 | 5.38 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076204 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5191060 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4796938 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5270743 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5195325 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2435614 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4777223 | PF-00835231 | EC50 | = | 39700.0 | nM | 4.40 |