Assay Detail
Functional
CHEMBL5320588
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Antitumor activity against human PC-3 cells assessed as cell growth inhibition
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.85 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405444 | — | — | 1 | 7.16 |
| CHEMBL3288601 | — | — | 1 | 4.78 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 4.76 |
| CHEMBL3288598 | — | — | 1 | 4.65 |
| CHEMBL3288599 | — | — | 1 | 4.49 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.05 |
| CHEMBL3288600 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405444 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3288601 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3288598 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL3288599 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL43612 | JUGLONE | IC50 | = | 88700.0 | nM | 4.05 |
| CHEMBL3288600 | — | IC50 | = | 92900.0 | nM | 4.03 |