Assay Detail
Functional
CHEMBL5322525
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Antiproliferative activity against human HGC-27 cells assessed as cell growth inhibition measured after 4 days by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.64 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094346 | — | — | 1 | 6.06 |
| CHEMBL5418787 | — | — | 1 | 5.63 |
| CHEMBL5435922 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094346 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5418787 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5435922 | — | IC50 | = | 6000.0 | nM | 5.22 |