Assay Detail
Functional
CHEMBL5322833
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Antiproliferative activity against human TMD8 cells assessed as inhibition of cell growth measured after 3 days by CCK-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.75 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403933 | — | — | 1 | 8.35 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 8.33 |
| CHEMBL5438294 | — | — | 1 | 8.03 |
| CHEMBL5431138 | — | — | 1 | 7.81 |
| CHEMBL5071105 | — | — | 1 | 7.34 |
| CHEMBL5413602 | — | — | 1 | 7.33 |
| CHEMBL5407364 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403933 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5438294 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5431138 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5071105 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL5413602 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5407364 | — | IC50 | = | 82.1 | nM | 7.09 |