Assay Detail
Binding
CHEMBL5322841
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Inhibition of avian Influenza A virus SN 33 (H1N1) neuraminidase infected in dog MDCK cells using MU-NANA as substrate assessed as reduction in viral replication incubated for 72 hrs by spectrofluorometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Conformationally locked sugar derivatives and analogues as potential neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.42 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3951068 | — | — | 1 | 7.70 |
| CHEMBL4459836 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3951068 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4459836 | — | IC50 | = | 74.9 | nM | 7.13 |