Assay Detail
Binding
CHEMBL5322975
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Inhibition of ATR (unknown origin)
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 8.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394792 | — | — | 1 | 9.00 |
| CHEMBL5417125 | — | — | 1 | 8.92 |
| CHEMBL5434673 | — | — | 1 | 8.82 |
| CHEMBL5397045 | — | — | 1 | 8.70 |
| CHEMBL5438872 | — | — | 1 | 8.64 |
| CHEMBL5421836 | — | — | 1 | 8.55 |
| CHEMBL5400072 | — | — | 1 | 8.55 |
| CHEMBL5399336 | — | — | 1 | 8.54 |
| CHEMBL5423686 | — | — | 1 | 8.51 |
| CHEMBL5417397 | — | — | 1 | 8.51 |
| CHEMBL5418001 | — | — | 1 | 8.46 |
| CHEMBL5406933 | — | — | 1 | 8.44 |
| CHEMBL5414136 | — | — | 1 | 8.43 |
| CHEMBL5419522 | — | — | 1 | 8.42 |
| CHEMBL2325697 | — | — | 1 | 8.39 |
| CHEMBL5431164 | — | — | 1 | 8.35 |
| CHEMBL5416256 | — | — | 1 | 8.33 |
| CHEMBL5402654 | — | — | 1 | 8.30 |
| CHEMBL5395096 | — | — | 1 | 8.27 |
| CHEMBL5422586 | — | — | 1 | 8.26 |
| CHEMBL5422401 | — | — | 1 | 8.24 |
| CHEMBL5425632 | — | — | 1 | 8.24 |
| CHEMBL5402268 | — | — | 1 | 8.21 |
| CHEMBL5432830 | — | — | 1 | 8.21 |
| CHEMBL5414995 | — | — | 1 | 8.10 |
| CHEMBL5424696 | — | — | 1 | 8.07 |
| CHEMBL5430998 | — | — | 1 | 8.02 |
| CHEMBL5413056 | — | — | 1 | 7.88 |
| CHEMBL5431183 | — | — | 1 | 7.78 |
| CHEMBL5419026 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394792 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5417125 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5434673 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5397045 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5438872 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5421836 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5400072 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5399336 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5423686 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5417397 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5418001 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5406933 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5414136 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5419522 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2325697 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5431164 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5416256 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5402654 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5395096 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5422586 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5425632 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5422401 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5402268 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5432830 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5414995 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5424696 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5430998 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5413056 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5431183 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL5419026 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL5394774 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL5422986 | — | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL5429107 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL5419094 | — | IC50 | = | 35.3 | nM | 7.45 |
| CHEMBL5436733 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5440035 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL5414755 | — | IC50 | = | 59.2 | nM | 7.23 |
| CHEMBL5438078 | — | IC50 | = | 108.5 | nM | 6.96 |
| CHEMBL5420070 | — | IC50 | = | 113.5 | nM | 6.95 |
| CHEMBL5410167 | — | IC50 | = | 122.7 | nM | 6.91 |
| CHEMBL5438263 | — | IC50 | = | 159.2 | nM | 6.80 |
| CHEMBL5416889 | — | IC50 | = | 233.3 | nM | 6.63 |