Assay Detail
Functional
CHEMBL5322976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LoVo cells incubated for 72 hrs by CCK-8 assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.53 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | 1.0 | 1 | 7.39 |
| CHEMBL5394792 | — | — | 1 | 7.19 |
| CHEMBL5417125 | — | — | 1 | 7.14 |
| CHEMBL5434673 | — | — | 1 | 7.14 |
| CHEMBL5431164 | — | — | 1 | 7.05 |
| CHEMBL5421836 | — | — | 1 | 6.97 |
| CHEMBL5425632 | — | — | 1 | 6.96 |
| CHEMBL5432830 | — | — | 1 | 6.95 |
| CHEMBL5422586 | — | — | 1 | 6.93 |
| CHEMBL5406933 | — | — | 1 | 6.92 |
| CHEMBL5413056 | — | — | 1 | 6.90 |
| CHEMBL5416256 | — | — | 1 | 6.82 |
| CHEMBL5400072 | — | — | 1 | 6.75 |
| CHEMBL5414995 | — | — | 1 | 6.66 |
| CHEMBL5422401 | — | — | 1 | 6.65 |
| CHEMBL5417397 | — | — | 1 | 6.59 |
| CHEMBL5423686 | — | — | 1 | 6.58 |
| CHEMBL5424696 | — | — | 1 | 6.58 |
| CHEMBL5414136 | — | — | 1 | 6.44 |
| CHEMBL5429107 | — | — | 1 | 6.43 |
| CHEMBL5402268 | — | — | 1 | 6.43 |
| CHEMBL5397045 | — | — | 1 | 6.42 |
| CHEMBL5430998 | — | — | 1 | 6.41 |
| CHEMBL5395096 | — | — | 1 | 6.40 |
| CHEMBL5402654 | — | — | 1 | 6.36 |
| CHEMBL5399336 | — | — | 1 | 6.28 |
| CHEMBL5418001 | — | — | 1 | 6.20 |
| CHEMBL5431183 | — | — | 1 | 6.20 |
| CHEMBL5438872 | — | — | 1 | 6.19 |
| CHEMBL5419522 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5394792 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5434673 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5417125 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5431164 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5421836 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5425632 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5432830 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5422586 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5406933 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5413056 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5416256 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5400072 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5414995 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5422401 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5417397 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL5423686 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5424696 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL5414136 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5429107 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5402268 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL5397045 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL5430998 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL5395096 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL5402654 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL5399336 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL5418001 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL5431183 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL5438872 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL5419522 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL5394774 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL5419094 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL5422986 | — | IC50 | = | 1495.0 | nM | 5.83 |
| CHEMBL5414755 | — | IC50 | = | 1887.0 | nM | 5.72 |
| CHEMBL5440035 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL5419026 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL5416889 | — | IC50 | - | — | - | |
| CHEMBL5438078 | — | IC50 | - | — | - | |
| CHEMBL5410167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5420070 | — | IC50 | - | — | - | |
| CHEMBL5436733 | — | IC50 | - | — | - | |
| CHEMBL5438263 | — | IC50 | - | — | - |