Assay Detail
Toxicity
CHEMBL5324508
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Inhibition of hERG expressed in CHO cells at holding potential of -80 mV measured for 15 seconds by whole cell patch clamp assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of WLB-89462, a New Drug-like and Highly Selective σ<sub>2</sub> Receptor Ligand with Neuroprotective Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.30 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394618 | — | — | 1 | 5.44 |
| CHEMBL5418939 | — | — | 1 | 5.38 |
| CHEMBL5426449 | — | — | 1 | 5.35 |
| CHEMBL5400448 | — | — | 1 | 5.27 |
| CHEMBL5425053 | — | — | 1 | 5.06 |
| CHEMBL5398618 | — | — | 1 | - |
| CHEMBL5401020 | — | — | 1 | - |
| CHEMBL5427726 | — | — | 1 | - |
| CHEMBL5418322 | — | — | 1 | - |
| CHEMBL5395523 | — | — | 1 | - |
| CHEMBL5426097 | — | — | 1 | - |
| CHEMBL5424034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394618 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5418939 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5426449 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5400448 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5425053 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5398618 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5395523 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5426097 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5424034 | — | IC50 | > | 10000.0 | nM | - |