Assay Detail
Functional
CHEMBL5324541
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Antiviral activity against Hepatitis B virus ayw1 infected in human HepG2 2.2.15 cells assessed as reduction in viral DNA replication preincubated for 3 days followed by media replacement and measured after 6 days by q-PCR assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiviral Evaluation of Dispirotripiperazines against Hepatitis B Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.80 | 7.75 |
| EC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | 7.75 |
| CHEMBL5401528 | — | — | 2 | 5.73 |
| CHEMBL5404122 | — | — | 2 | 5.67 |
| CHEMBL5419785 | — | — | 2 | 5.18 |
| CHEMBL5399584 | — | — | 2 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5401528 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5404122 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5419785 | — | EC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL5399584 | — | EC50 | = | 22040.0 | nM | 4.66 |
| CHEMBL5404122 | — | EC90 | = | 26.5 | uM | - |
| CHEMBL5419785 | — | EC90 | = | 58.15 | uM | - |
| CHEMBL5401528 | — | EC90 | = | 15.67 | uM | - |
| CHEMBL5399584 | — | EC90 | = | 78.12 | uM | - |
| CHEMBL141 | LAMIVUDINE | EC90 | = | 0.541 | uM | - |