Assay Detail
Functional
CHEMBL5324841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.66 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1742248 | — | — | 1 | 6.82 |
| CHEMBL3314206 | — | — | 1 | 5.79 |
| CHEMBL17291 | CAFFEOYL ALDEHYDE | — | 1 | 5.59 |
| CHEMBL5406128 | — | — | 1 | 5.41 |
| CHEMBL5430698 | — | — | 1 | 5.28 |
| CHEMBL242529 | CONIFERYL ALDEHYDE | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1742248 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3314206 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL17291 | CAFFEOYL ALDEHYDE | EC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5406128 | — | EC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL5430698 | — | EC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL242529 | CONIFERYL ALDEHYDE | EC50 | = | 9030.0 | nM | 5.04 |