Assay Detail
Binding
CHEMBL5324906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1 hr by MicroBeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.95 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403504 | — | — | 1 | 8.77 |
| CHEMBL5400876 | — | — | 1 | 8.66 |
| CHEMBL5437265 | — | — | 1 | 8.54 |
| CHEMBL2037521 | — | — | 1 | 8.51 |
| CHEMBL5426481 | — | — | 1 | 8.31 |
| CHEMBL5399720 | — | — | 1 | 8.21 |
| CHEMBL3289656 | — | — | 1 | 8.19 |
| CHEMBL5436702 | — | — | 1 | 8.00 |
| CHEMBL5400983 | — | — | 1 | 7.94 |
| CHEMBL5406300 | — | — | 1 | 7.67 |
| CHEMBL5425920 | — | — | 1 | 7.67 |
| CHEMBL5434856 | — | — | 1 | 7.61 |
| CHEMBL5394387 | — | — | 1 | 7.58 |
| CHEMBL5403986 | — | — | 1 | 7.57 |
| CHEMBL5422150 | — | — | 1 | 7.43 |
| CHEMBL5399689 | — | — | 1 | 7.34 |
| CHEMBL5403610 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403504 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5400876 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL5437265 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL2037521 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL5426481 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL5399720 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL3289656 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL5436702 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL5400983 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL5406300 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL5425920 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL5434856 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL5394387 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5403986 | — | Ki | = | 27.2 | nM | 7.57 |
| CHEMBL5422150 | — | Ki | = | 36.7 | nM | 7.43 |
| CHEMBL5399689 | — | Ki | = | 45.8 | nM | 7.34 |
| CHEMBL5403610 | — | Ki | = | 59.0 | nM | 7.23 |