Assay Detail
Binding
CHEMBL5324907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1 hr by MicroBeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.18 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436702 | — | — | 1 | 7.23 |
| CHEMBL2037521 | — | — | 1 | 7.03 |
| CHEMBL5426481 | — | — | 1 | 6.98 |
| CHEMBL5425920 | — | — | 1 | 6.69 |
| CHEMBL5403986 | — | — | 1 | 6.65 |
| CHEMBL5406300 | — | — | 1 | 6.64 |
| CHEMBL5403504 | — | — | 1 | 6.54 |
| CHEMBL5422150 | — | — | 1 | 6.29 |
| CHEMBL5394387 | — | — | 1 | 6.11 |
| CHEMBL5400876 | — | — | 1 | 5.94 |
| CHEMBL5437265 | — | — | 1 | 5.88 |
| CHEMBL5400983 | — | — | 1 | 5.81 |
| CHEMBL3289656 | — | — | 1 | 5.78 |
| CHEMBL5434856 | — | — | 1 | 5.31 |
| CHEMBL5399720 | — | — | 1 | 5.14 |
| CHEMBL5399689 | — | — | 1 | 4.93 |
| CHEMBL5403610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436702 | — | Ki | = | 58.5 | nM | 7.23 |
| CHEMBL2037521 | — | Ki | = | 93.2 | nM | 7.03 |
| CHEMBL5426481 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL5425920 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL5403986 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL5406300 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL5403504 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL5422150 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL5394387 | — | Ki | = | 773.0 | nM | 6.11 |
| CHEMBL5400876 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL5437265 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL5400983 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL3289656 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL5434856 | — | Ki | = | 4860.0 | nM | 5.31 |
| CHEMBL5399720 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL5399689 | — | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL5403610 | — | Ki | = | 201000.0 | nM | - |