Assay Detail
Binding
CHEMBL5324908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1 hr by MicroBeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.62 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037521 | — | — | 1 | 6.90 |
| CHEMBL5436702 | — | — | 1 | 6.39 |
| CHEMBL5399720 | — | — | 1 | 6.37 |
| CHEMBL5403504 | — | — | 1 | 6.29 |
| CHEMBL5406300 | — | — | 1 | 6.17 |
| CHEMBL5426481 | — | — | 1 | 6.08 |
| CHEMBL5425920 | — | — | 1 | 5.98 |
| CHEMBL5437265 | — | — | 1 | 5.80 |
| CHEMBL5403986 | — | — | 1 | 5.62 |
| CHEMBL5400876 | — | — | 1 | 5.53 |
| CHEMBL3289656 | — | — | 1 | 5.20 |
| CHEMBL5422150 | — | — | 1 | 5.19 |
| CHEMBL5399689 | — | — | 1 | 5.16 |
| CHEMBL5394387 | — | — | 1 | 4.88 |
| CHEMBL5400983 | — | — | 1 | 4.85 |
| CHEMBL5434856 | — | — | 1 | 4.76 |
| CHEMBL5403610 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037521 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL5436702 | — | Ki | = | 408.0 | nM | 6.39 |
| CHEMBL5399720 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL5403504 | — | Ki | = | 519.0 | nM | 6.29 |
| CHEMBL5406300 | — | Ki | = | 669.0 | nM | 6.17 |
| CHEMBL5426481 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL5425920 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL5437265 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL5403986 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL5400876 | — | Ki | = | 2930.0 | nM | 5.53 |
| CHEMBL3289656 | — | Ki | = | 6370.0 | nM | 5.20 |
| CHEMBL5422150 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL5399689 | — | Ki | = | 6890.0 | nM | 5.16 |
| CHEMBL5394387 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL5400983 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL5434856 | — | Ki | = | 17400.0 | nM | 4.76 |
| CHEMBL5403610 | — | Ki | = | 49800.0 | nM | 4.30 |