Assay Detail
Functional
CHEMBL5324922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.59 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.92 |
| CHEMBL2037521 | — | — | 1 | 6.62 |
| CHEMBL5403504 | — | — | 1 | 6.38 |
| CHEMBL5436702 | — | — | 1 | 6.07 |
| CHEMBL5425920 | — | — | 1 | 5.81 |
| CHEMBL5406300 | — | — | 1 | 5.65 |
| CHEMBL5399689 | — | — | 1 | 5.56 |
| CHEMBL5399720 | — | — | 1 | 5.35 |
| CHEMBL5437265 | — | — | 1 | 5.19 |
| CHEMBL5400876 | — | — | 1 | 5.00 |
| CHEMBL5394387 | — | — | 1 | 5.00 |
| CHEMBL3289656 | — | — | 1 | 4.99 |
| CHEMBL5434856 | — | — | 1 | 4.84 |
| CHEMBL5403610 | — | — | 1 | 4.81 |
| CHEMBL5426481 | — | — | 1 | 4.64 |
| CHEMBL5403986 | — | — | 1 | 4.62 |
| CHEMBL5400983 | — | — | 1 | - |
| CHEMBL5422150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2037521 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL5403504 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL5436702 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL5425920 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5406300 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5399689 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL5399720 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL5437265 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL5400876 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5394387 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL3289656 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5434856 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5403610 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5426481 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5403986 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL5400983 | — | IC50 | - | — | - | |
| CHEMBL5422150 | — | IC50 | - | — | - |