Assay Detail
Binding
CHEMBL5325032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal his6-tagged mouse EGFR by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.48 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440872 | — | — | 1 | 8.10 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 7.70 |
| CHEMBL5429059 | — | — | 1 | 7.30 |
| CHEMBL5438568 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440872 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5429059 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5438568 | — | IC50 | = | 158.49 | nM | 6.80 |