Assay Detail
Binding
CHEMBL5325200
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Binding affinity to C-terminal His-tagged human HDAC2 (2 to 488 residues) in transfected in baculovirus infected Sf9 cells assessed as dissociation constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.26 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.92 |
| CHEMBL470791 | — | — | 1 | 7.60 |
| CHEMBL235842 | — | — | 1 | 7.42 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.79 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL470791 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL235842 | — | Kd | = | 38.0 | nM | 7.42 |
| CHEMBL98 | VORINOSTAT | Kd | = | 163.0 | nM | 6.79 |
| CHEMBL27759 | ENTINOSTAT | Kd | = | 282.0 | nM | 6.55 |