Assay Detail
Binding
CHEMBL5325219
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Binding affinity to HDAC2 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.77 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.33 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.33 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL235191 | TACEDINALINE | Ki | = | 2190.0 | nM | 5.66 |