Assay Detail
Binding
CHEMBL5325513
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Binding affinity to VIM-1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-Vis spectrophotometric analysis
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 5.66 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5432082 | — | — | 1 | 6.39 |
| CHEMBL5433574 | — | — | 1 | 6.25 |
| CHEMBL5414177 | — | — | 1 | 6.23 |
| CHEMBL5413869 | — | — | 1 | 6.16 |
| CHEMBL1452412 | — | — | 1 | 6.14 |
| CHEMBL5399621 | — | — | 1 | 6.12 |
| CHEMBL5431803 | — | — | 1 | 6.12 |
| CHEMBL5401341 | — | — | 1 | 5.92 |
| CHEMBL5401163 | — | — | 1 | 5.92 |
| CHEMBL5425633 | — | — | 1 | 5.89 |
| CHEMBL5422147 | — | — | 1 | 5.85 |
| CHEMBL5415017 | — | — | 1 | 5.80 |
| CHEMBL5412062 | — | — | 1 | 5.72 |
| CHEMBL5402541 | — | — | 1 | 5.68 |
| CHEMBL5419605 | — | — | 1 | 5.66 |
| CHEMBL5410303 | — | — | 1 | 5.66 |
| CHEMBL5414194 | — | — | 1 | 5.51 |
| CHEMBL2153287 | — | — | 1 | 5.50 |
| CHEMBL5396611 | — | — | 1 | 5.50 |
| CHEMBL5421071 | — | — | 1 | 5.48 |
| CHEMBL5404243 | — | — | 1 | 5.48 |
| CHEMBL5397732 | — | — | 1 | 5.44 |
| CHEMBL5438562 | — | — | 1 | 5.43 |
| CHEMBL5414834 | — | — | 1 | 5.29 |
| CHEMBL5431286 | — | — | 1 | 5.20 |
| CHEMBL5399604 | — | — | 1 | 4.96 |
| CHEMBL5407126 | — | — | 1 | 4.64 |
| CHEMBL5409951 | — | — | 1 | 4.57 |
| CHEMBL5404284 | — | — | 1 | - |
| CHEMBL5438176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5432082 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL5433574 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL5414177 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL5413869 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1452412 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL5399621 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL5431803 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL5401341 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5401163 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5425633 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL5422147 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL5415017 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5412062 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL5402541 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL5410303 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL5419605 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL5414194 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL2153287 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL5396611 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL5421071 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL5404243 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL5397732 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL5438562 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL5414834 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL5431286 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL5399604 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL5407126 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL5409951 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL5406560 | — | Ki | - | — | - | |
| CHEMBL5407957 | — | Ki | - | — | - | |
| CHEMBL5436669 | — | Ki | - | — | - | |
| CHEMBL5417692 | — | Ki | - | — | - | |
| CHEMBL5437278 | — | Ki | - | — | - | |
| CHEMBL1352550 | — | Ki | - | — | - | |
| CHEMBL5397771 | — | Ki | - | — | - | |
| CHEMBL5415745 | — | Ki | - | — | - | |
| CHEMBL5438176 | — | Ki | - | — | - | |
| CHEMBL5404284 | — | Ki | - | — | - |