Assay Detail
Binding
CHEMBL5325515
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Binding affinity to VIM-4 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-Vis spectrophotometric analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.80 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798128 | — | — | 1 | 7.40 |
| CHEMBL5422147 | — | — | 1 | 6.40 |
| CHEMBL5401341 | — | — | 1 | 6.37 |
| CHEMBL5399604 | — | — | 1 | 6.27 |
| CHEMBL4754134 | — | — | 1 | 6.22 |
| CHEMBL5425633 | — | — | 1 | 6.17 |
| CHEMBL5413869 | — | — | 1 | 6.10 |
| CHEMBL5432082 | — | — | 1 | 6.09 |
| CHEMBL5399621 | — | — | 1 | 6.07 |
| CHEMBL5401163 | — | — | 1 | 6.05 |
| CHEMBL5433574 | — | — | 1 | 6.05 |
| CHEMBL5397732 | — | — | 1 | 5.96 |
| CHEMBL5412062 | — | — | 1 | 5.82 |
| CHEMBL1452412 | — | — | 1 | 5.82 |
| CHEMBL5437278 | — | — | 1 | 5.80 |
| CHEMBL5414177 | — | — | 1 | 5.75 |
| CHEMBL5415017 | — | — | 1 | 5.72 |
| CHEMBL5395243 | — | — | 1 | 5.68 |
| CHEMBL5396611 | — | — | 1 | 5.68 |
| CHEMBL5402541 | — | — | 1 | 5.64 |
| CHEMBL5421071 | — | — | 1 | 5.62 |
| CHEMBL5419605 | — | — | 1 | 5.60 |
| CHEMBL5410303 | — | — | 1 | 5.60 |
| CHEMBL5404243 | — | — | 1 | 5.50 |
| CHEMBL5414834 | — | — | 1 | 5.39 |
| CHEMBL5431803 | — | — | 1 | 5.11 |
| CHEMBL5431286 | — | — | 1 | 5.09 |
| CHEMBL4757595 | — | — | 1 | 5.05 |
| CHEMBL5409951 | — | — | 1 | 4.22 |
| CHEMBL5436669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798128 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5422147 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL5401341 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL5399604 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL4754134 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL5425633 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL5413869 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL5432082 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL5399621 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL5401163 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL5433574 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL5397732 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL5412062 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1452412 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL5437278 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5414177 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL5415017 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL5395243 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL5396611 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL5402541 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL5421071 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL5419605 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL5410303 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL5404243 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL5414834 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL5431803 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL5431286 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL4757595 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL5409951 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL5436669 | — | Ki | - | — | - | |
| CHEMBL5404284 | — | Ki | - | — | - | |
| CHEMBL5406560 | — | Ki | - | — | - | |
| CHEMBL5415745 | — | Ki | - | — | - |