Assay Detail
Binding
CHEMBL5325517
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Binding affinity to IMP1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-Vis spectrophotometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.01 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754134 | — | — | 1 | 7.00 |
| CHEMBL5410303 | — | — | 1 | 5.34 |
| CHEMBL5416426 | — | — | 1 | 5.28 |
| CHEMBL1452412 | — | — | 1 | 5.10 |
| CHEMBL5425633 | — | — | 1 | 5.04 |
| CHEMBL5431286 | — | — | 1 | 5.01 |
| CHEMBL4757595 | — | — | 1 | 4.92 |
| CHEMBL5421071 | — | — | 1 | 4.85 |
| CHEMBL5433574 | — | — | 1 | 4.85 |
| CHEMBL4798128 | — | — | 1 | 4.75 |
| CHEMBL5412062 | — | — | 1 | 4.70 |
| CHEMBL5413869 | — | — | 1 | 4.70 |
| CHEMBL5404243 | — | — | 1 | 4.62 |
| CHEMBL5414834 | — | — | 1 | 4.57 |
| CHEMBL5402541 | — | — | 1 | 4.38 |
| CHEMBL5414194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754134 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5410303 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL5416426 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL1452412 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL5425633 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL5431286 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL4757595 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL5421071 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL5433574 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4798128 | — | Ki | = | 17700.0 | nM | 4.75 |
| CHEMBL5412062 | — | Ki | = | 20200.0 | nM | 4.70 |
| CHEMBL5413869 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL5404243 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL5414834 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL5402541 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL5414194 | — | Ki | - | — | - |